Figure 1.

PDAC utilize autophagy for maintaining cysteine homeostasis by regulating SLC7A11. Under autophagy-compromised conditions, SLC7A11 is phosphorylated at Ser26 by MTORC2, which promotes the translocation from the plasma membrane to the lysosome leading to its inactivation. Disruption of autophagy leads to pancreatic tumor shrinkage thereby highlighting the therapeutic significance. This figure is adapted from Fig. 5 in ref [1]