Figure 7.

A. Properties with highest impact on clearance after 10000 runs of the random forest. B. Sequence based isoelectric point using the modeled Fv region (pI_seq) plotted against the poly specificity reagent (PSR). Antibodies colored blue have clearance less than or equal 2.5 mL/day/kg, antibodies colored green have clearance between 2.5 and 5.4 mL/day/kg. Antibodies with fast clearance >5.4 mL/day/kg are colored in red. Marker size is proportional to the magnitude of the clearance. Marker type indicates antibody isotype. C. Cutoff criteria and accuracy for separating normal clearing and fast clearing antibodies for pI_seq and PSR