ACSINS | Affinity-capture self-interaction nanoparticle spectroscopy |
ADA | Anti-drug antibodies |
CDR | Complementarity-determining region |
CL | Clearance |
Fc | Crystalizable fragment |
FcRn | Neonatal Fc receptor |
Fv | Variable fragment |
Fvcharge5.5 | Net antibody Fv charge at pH 5.5 |
HI_sum | Hydrophobic index along three CDRs |
IgG | Immunoglobulin G |
mAb | Monoclonal antibody |
MMAE | Monomethyl-Auristatin E |
Patch_cdr_hyd | Surface area of the hydrophobic patches near the CDRs |
pI | Isoelectric point |
pI_3D | Structure-based pI prediction |
pI_seq | Sequence-based pI prediction |
PK | Pharmacokinetics |
PSR | Poly-specificity reagent |
TAP | Therapeutic antibody profiler |
TMDD | Target-mediated drug disposition |