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. 2021 Jun 12;28(1):1166–1178. doi: 10.1080/10717544.2021.1934191

Figure 6.

Figure 6.

Serology assessment. (a) Blood samples of mouse xenograft tumor models were collected and subjected to detect inflammatory cytokines (TNF-α, IL-1, IL-6, IL-12, IFN-α, IFN-β, IFN-γ, and IL-8) (* indicated p < .05 compared with the saline group; ** indicated p < 0.01 compared with the saline group). (b) SSFH/Cas9 prevent development of cytokine storm. When the SSFH/Cas9 group and the CD123 antibody group exhibited an obvious difference compared with the saline group, agent injections should be ended. Mice in the saline group and the CD123 antibody group were injected with saline and mice in the SSFH/Cas9/sgRNA group were injected with the complementary sequence of SS30. Three days later, blood samples of mice were collected and subjected to detect inflammatory cytokines. (* indicated p < .05 compared with before SS30 complementary sequence injection; ** indicated p < .01 compared with before SS30 complementary sequence injection).