Effect of selective PI3K inhibitors on melanoma cell viability. Melanoma cells were treated for 72 h with concentrations ranging from 0.01 µM to 0.5 µM of (a) pan-PI3K (BKM120), (b) PI3Kα (BYL719), (c) PI3Kβ (TGX221), (d) PI3Kβ (GSK2636771), (e) PI3Kγ (AS252424), (f) PI3Kδ (GSK2269557). Cell viability was determined by an MTT assay. Data represent the mean (SD) of three independent experiments