TABLE 1.

Study Characteristics and Findings of Included Studies

References; Sample Size	Animal Strain, Species, Age	Sepsis Model	Control Group	Antibiotic Used	Dose, No. of Doses, Route of Administration, Time of Administration	Outcomes	Findings
Das et al (23); n = 190 (~40–75 with sex-stratified data reported)	C57BL/6, mice, 10–12 wk	CLP	No treatment	Imipenem/cilastatin	5 mg/kg, every 12 hr for 7 d, subcutaneous injection, 30 min after sepsis induction	Standardized Histological Injury Scores (heart, lung, liver, spleen, kidney, gut, brain, ovary, testis)	No significant differences between males and females
Lewis et al (24); n = 200 (50 total with sex-stratified data reported)	C57BL/6, mice, 8–12 wk	CLP	No treatment/low-dose antibiotics	Imipenem/cilastatin	25 mg/kg, 1, intraperitoneal injection, 0 and 4 hr after meeting criteria for physiologic deterioration	Mortality	Males had greater treatment response than females

CLP = cecal ligation and puncture.