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(a) Classes of β-lactam antibiotics. (b) Outline of the MBL hydrolysis mechanism. Ligands around the zinc ions are not shown for clarity. (c) Representative SBL inhibitors. (d) Representative MBL inhibitors29−31 with sulfonamide ANT268119 and related sulfonamide and sulfamoyl inhibitors.21,22,32 Zinc-chelating functional groups are highlighted in blue.
