Table 1.
UGT 2B10 Genotype | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Asp67Tyr Variant (rs6175900) | Splice variant (rs116294140) | Both variants | |||||||||||||
ALL* | ALL* | African Americans | All | ||||||||||||
N | means | (95% CI) | N | means | (95% CI) | N | means | (95% CI) | Genetic ScoreϮ | N | means | (95% CI) | |||
Measures of Enzyme Activity | |||||||||||||||
UGT2B10 | |||||||||||||||
Nicotine glucuronide/ nicotine | GG | 2028 | 0.377 | (0.344–0.414) | AA | 1853 | 0.39 | (0.352–0.429) | 156 | 0.31 | (0.225–0.421) | 0 | 1664 | 0.45 | (0.402–0.496) |
GT | 204 | 0.126 | (0.08–0.201) | CA | 333 | 0.23 | (0.128–0.411) | 166 | 0.19 | (0.143–0.264) | 1 | 503 | 0.19 | (0.155–0.224) | |
TT§ | 2 | 0.00 | CC§ | 48 | 0.01 | (0.008–0.027) | 41 | 0.02 | (0.01–0.036) | 2§ | 67 | 0.00 | (0–0.001) | ||
p-value** | <.0001 | <0.0001 | <.0001 | <0.0001 | |||||||||||
Cotinine glucuronide/ cotinine | GG | 2031 | 1.12 | (1.07–1.17) | AA | 1857 | 1.28 | (1.22–1.38) | 157 | 1.10 | (0.97–1.24)† | 0 | 1668 | 1.38 | (1.33–1.44) |
GT | 205 | 0.54 | (0.43–0.68) | CA | 333 | 0.63 | (0.5–0.80) | 166 | 0.48 | (0.42–0.54) | 1 | 504 | 0.68 | (0.63–0.73) | |
TT§ | 1 | 0.01 | CC§ | 47 | 0.02 | (0.02–0.03) | 40 | 0.02 | (0.02–0.03) | 2§ | 65 | 0.01 | (0.005–0.013) | ||
p-value** | <0.0001 | <0.0001 | <.0001 | <0.0001 | |||||||||||
CYP2A6 | |||||||||||||||
Total 3-HCOT/Total Cotinine | GG | 2032 | 1.38 | (1.34–1.43) | AA | 1858 | 1.33 | (1.29–1.38) | 157 | 1.65 | (1.469–1.853) | 0 | 1668 | 1.29 | (1.24–1.34) |
GT | 205 | 1.84 | (1.56–2.18) | CA | 333 | 1.63 | (1.31–2.02) | 166 | 2.24 | (2.003–2.513) | 1 | 504 | 1.78 | (1.66–1.90) | |
TT§ | 2 | 4.06 | (2.82–5.30) | CC§ | 48 | 3.76 | (3.03–4.67) | 41 | 4.75 | (3.794–5.952) | 2§ | 67 | 3.09 | (2.04–4.69) | |
p-value** | 0.0011 | 0.0006 | <.0001 | <0.0001 | |||||||||||
Total 3-HCOT/Cotinine | GG | 2031 | 3.21 | (3.10–3.32) | AA | 1857 | 3.23 | (3.11–3.35) | 157 | 3.78 | (3.35–4.26) | 0 | 1668 | 3.23 | (3.10–3.37) |
GT | 205 | 3.35 | (2.82–3.98) | CA | 333 | 2.90 | (2.32–3.63) | 166 | 3.64 | (3.23–4.09) | 1 | 504 | 3.19 | (2.97–3.43) | |
TT§ | 1 | 5.35 | CC§ | 47 | 3.72 | (2.97–4.66) | 40 | 4.52 | (3.57–5.72) | 2§ | 65 | 3.11 | (2.01–4.81) | ||
p-value** | 0.631 | 0.6264 | 0.2706 | 0.9452 |
Incudes all 5 ethnic groups, values are adjusted for age, sex, creatinine (natural log), BMI (natural log), and race
Adjusted for age, sex, creatinine (natural log), BMI (natural log)
Genetic score 0, rs61750900 GG and rs116294140 AA; score 1, rs61750900 GT or rs116294140 CA; score 2, rs61750900 TT or rs116294140 CC, or both rs61750900 GT and rs116294140 CA
if n<10 the mean (minimum-maximum) are presented, not the geometric means and 95% Cis