Table 1.
Geometric means of nicotine metabolite ratios stratified by UGT2B10 genotype9.
| UGT 2B10 Genotype | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Asp67Tyr Variant (rs6175900) | Splice variant (rs116294140) | Both variants | |||||||||||||
| ALL* | ALL* | African Americans | All | ||||||||||||
| N | means | (95% CI) | N | means | (95% CI) | N | means | (95% CI) | Genetic ScoreϮ | N | means | (95% CI) | |||
| Measures of Enzyme Activity | |||||||||||||||
| UGT2B10 | |||||||||||||||
| Nicotine glucuronide/ nicotine | GG | 2028 | 0.377 | (0.344–0.414) | AA | 1853 | 0.39 | (0.352–0.429) | 156 | 0.31 | (0.225–0.421) | 0 | 1664 | 0.45 | (0.402–0.496) |
| GT | 204 | 0.126 | (0.08–0.201) | CA | 333 | 0.23 | (0.128–0.411) | 166 | 0.19 | (0.143–0.264) | 1 | 503 | 0.19 | (0.155–0.224) | |
| TT§ | 2 | 0.00 | CC§ | 48 | 0.01 | (0.008–0.027) | 41 | 0.02 | (0.01–0.036) | 2§ | 67 | 0.00 | (0–0.001) | ||
| p-value** | <.0001 | <0.0001 | <.0001 | <0.0001 | |||||||||||
| Cotinine glucuronide/ cotinine | GG | 2031 | 1.12 | (1.07–1.17) | AA | 1857 | 1.28 | (1.22–1.38) | 157 | 1.10 | (0.97–1.24)† | 0 | 1668 | 1.38 | (1.33–1.44) |
| GT | 205 | 0.54 | (0.43–0.68) | CA | 333 | 0.63 | (0.5–0.80) | 166 | 0.48 | (0.42–0.54) | 1 | 504 | 0.68 | (0.63–0.73) | |
| TT§ | 1 | 0.01 | CC§ | 47 | 0.02 | (0.02–0.03) | 40 | 0.02 | (0.02–0.03) | 2§ | 65 | 0.01 | (0.005–0.013) | ||
| p-value** | <0.0001 | <0.0001 | <.0001 | <0.0001 | |||||||||||
| CYP2A6 | |||||||||||||||
| Total 3-HCOT/Total Cotinine | GG | 2032 | 1.38 | (1.34–1.43) | AA | 1858 | 1.33 | (1.29–1.38) | 157 | 1.65 | (1.469–1.853) | 0 | 1668 | 1.29 | (1.24–1.34) |
| GT | 205 | 1.84 | (1.56–2.18) | CA | 333 | 1.63 | (1.31–2.02) | 166 | 2.24 | (2.003–2.513) | 1 | 504 | 1.78 | (1.66–1.90) | |
| TT§ | 2 | 4.06 | (2.82–5.30) | CC§ | 48 | 3.76 | (3.03–4.67) | 41 | 4.75 | (3.794–5.952) | 2§ | 67 | 3.09 | (2.04–4.69) | |
| p-value** | 0.0011 | 0.0006 | <.0001 | <0.0001 | |||||||||||
| Total 3-HCOT/Cotinine | GG | 2031 | 3.21 | (3.10–3.32) | AA | 1857 | 3.23 | (3.11–3.35) | 157 | 3.78 | (3.35–4.26) | 0 | 1668 | 3.23 | (3.10–3.37) |
| GT | 205 | 3.35 | (2.82–3.98) | CA | 333 | 2.90 | (2.32–3.63) | 166 | 3.64 | (3.23–4.09) | 1 | 504 | 3.19 | (2.97–3.43) | |
| TT§ | 1 | 5.35 | CC§ | 47 | 3.72 | (2.97–4.66) | 40 | 4.52 | (3.57–5.72) | 2§ | 65 | 3.11 | (2.01–4.81) | ||
| p-value** | 0.631 | 0.6264 | 0.2706 | 0.9452 | |||||||||||
*
Incudes all 5 ethnic groups, values are adjusted for age, sex, creatinine (natural log), BMI (natural log), and race
**
Adjusted for age, sex, creatinine (natural log), BMI (natural log)
Ϯ
Genetic score 0, rs61750900 GG and rs116294140 AA; score 1, rs61750900 GT or rs116294140 CA; score 2, rs61750900 TT or rs116294140 CC, or both rs61750900 GT and rs116294140 CA
§
if n<10 the mean (minimum-maximum) are presented, not the geometric means and 95% Cis