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. 2021 May 7;4(3):1214–1226. doi: 10.1021/acsptsci.1c00064

Figure 3.

Figure 3

Inhibition of AID and A3B editing. (A) Fluorescent reporter assay in 293T cells. Guide RNA, dual plasmid reporter, and AID or A3B editors were added with compounds. Red and green fluorescence indicated transfection and editing, respectively. The ratio of double positive cells to mCherry positive cells was used to calculate relative editing frequencies. (B–D) Titration of compounds to measure effect on AID and A3B editing. Error bars represent the average of three independent experiments.