Skip to main content
. 2021 Jun 15;45:102046. doi: 10.1016/j.redox.2021.102046

Fig. 6.

Fig. 6

The balance between pro-inflammation cytokines (TNF-α, IL-3, IL-β, IL-6, IL-12, MIF and INF-γ) and anti-inflammation cytokines (IL-4, IL-10 and TGF-β) are significantly important in sepsis(A). The disordered homeostasis in sepsis can be regulated by nanomaterials through a variety of ways. It can be divided into three categories: (B) nanocarriers(chitosan derivatives, solid lipid nanoparticles, biomimetic nanoparticles) with anti-inflammation drugs can efficiently delivery anti-inflammation drugs (APS and Curcumin) into inflammation site; (C) nanoparticles with anti-inflammation capacity, including Au nanoparticles, SPIO nanoparticles, PLA/PLGA nanoparticles and macrophage/MSC nanovesicles; (D) nanomaterials targeting inflammatory cells (neutrophils and endothelial cells) could decrease the production of inflammation cytokines.