Table II.
Multivariate analysis for the association between biologics use and COVID-19 severity (moderate-severe) among adult asthmatic patients with positive PCR test result for SARS-CoV-2 (n = 8242)
| Variable | Adjusted∗ HR (95% CI) | P value |
|---|---|---|
| Age (for each year increase) | 1.053 (1.050-1.060) | <.001 |
| Sex | ||
| Males | 1.23 (1.02-1.48) | .033 |
| Females | Reference | |
| Ethnicity | ||
| Jews | Reference | |
| Arabs | 1.67 (1.38-2.01) | <.001 |
| Diabetes | 1.30 (1.07-1.57) | .009 |
| Hypertension | 1.36 (1.07-1.73) | .012 |
| Obesity | 1.40 (1.16-1.70) | .001 |
| IHD | 1.33 (1.09-1.63) | .006 |
| Smoking (ever) | 1.09 (0.90-1.32) | .381 |
| Steroids use in the previous year (no. of filled prescriptions) | ||
| None | Reference | |
| 1 prescription | 1.06 (0.81-1.39) | .655 |
| 2 prescriptions | 1.54 (1.10-2.15) | .012 |
| ≥3 prescriptions | 2.09 (1.65-2.65) | <.001 |
| Biologics use (at least 1 prescription filled in the previous 120 d) | ||
| None | Reference | |
| Yes | 1.28 (0.60-2.73) | .519 |
IHD, Ischemic heart disease.
∗
Adjusted for age, sex, ethnicity, diabetes, hypertension, IHD, obesity, smoking, and steroids and biologics use.