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. 2021 Jun 8;96(23):e2839–e2853. doi: 10.1212/WNL.0000000000012063

Figure 4. Average Marginal Probability for Functional Independence in Patients Receiving Bridging Therapy vs Direct EVT as Associated With NIHSS and Ischemic Core at Presentation.

Figure 4

(A) Graphical representation of the association of the marginal probability for functional independence (modified Rankin Scale [mRS] score 0–2) according to NIH Stroke Scale (NIHSS) score at presentation, stratified by the history of IV alteplase administration before endovascular thrombectomy (EVT). In patients with NIHSS score <15 (indicated by the blue area), average marginal probabilities are significantly higher in patients receiving bridging therapy (BT), whereas in patients with NIHSS score ≥15 (indicated by the red area), the difference between average marginal probabilities decreases and then inverts so that the average marginal probabilities for direct EVT is higher than for BT. (B) Graphical representation of the association of the marginal probability for functional independence (mRS score 0–2) according to baseline ischemic core volume, stratified by the history of IV alteplase administration before EVT. In patients with ischemic core <50 mL (indicated by the blue area), average marginal probabilities are significantly higher in patients receiving BT, whereas in patients with ischemic core ≥50 mL (indicated by the red area), the difference between average marginal probabilities decreases and marginal probabilities in both groups become almost similar as the ischemic core size increases.