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. 2021 May 18;96(20):e2481–e2487. doi: 10.1212/WNL.0000000000011931

Figure 2. Instrumental Estimates of Migraine and Migraine Without Aura (MO) With Hemostatic Profiles.

Figure 2

Instrumental estimates of hemostatic profiles with (A) migraine and (B) MO. All the analyses for migraine without aura were estimated using inverse variance–weighted (IVW) Mendelian randomization implemented in the R package TwoSampleMR due to limited number of instruments (less than 10). As migraine is a binary variable, the reverse causal estimates were scaled to reflect the average change in hemostatic factors (in native units specific to each factor) per doubling (2-fold increase) in prevalence of migraine (Methods). aPTT = activated partial thromboplastin time; FVII = coagulation factor VII; FVIII = coagulation factor VIII; FXI = coagulation factor XI; PAI-1 = plasminogen activator inhibitor-1; PT/INR = prothrombin time/international normalized ratio; tPA = tissue plasminogen activator; vWF = von Willebrand factor.