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. 2021 May 18;96(20):e2481–e2487. doi: 10.1212/WNL.0000000000011931

Figure 3. Multivariable Mendelian Randomization Analysis of Coagulation Factor VIII (FVIII) and von Willebrand Factor (vWF) With Migraine, Migraine With Aura, and Migraine Without Aura.

Figure 3

Conditional instrumental analyses were first performed using multi-trait–based conditional and joint analysis (mtCOJO) implemented in generalized summary data–based Mendelian randomization and then the instrumental estimates were calculated using inverse variance–weighted Mendelian randomization implemented in the R package TwoSampleMR based on the conditioned instruments. All the instrumental estimates were interpreted as the odds ratio of per SD change of FVIII and vWF.