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. 2021 Jun 16;11(6):210047. doi: 10.1098/rsob.210047

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© 2021 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 3. — The role of SIRT7 in DNA repair. (a) In response to DNA damage, SIRT7 is recruited to DSBs that depend on PARP1, where it deacetylates H3K18ac and allows 53bp1 recruitment for the repair via the NHEJ pathway. After its recruitment to chromatin, SIRT7 mediates H3K122 desuccinylation and H4K91 deglutarylation for chromatin compaction necessary for DNA repair. (b) In response to DNA damage, ATM is sequentially modified by acetylation and phosphorylation before ATM dissociates into an active monomer. At the late stage of DNA damage and repair, SIRT7 is gradually recruited to DNA damage sites and deacetylates ATM; this process facilitates ATM dephosphorylation by WIP1. After complete repair, ATM dimerizes into an inactive form.