Table 1.

SIRT7 targets.

substrate	activity	functions
p53	deacetylation	apoptosis, heart hypertrophy and inflammatory cardiomyopathy [17]
H3K18	deacetylation	oncogenic transformation [14]
DAF-16	deacetylation	stress response [18]
PAF53	deacetylation	pre-rRNA processing [19]
NPM1	deacetylation	ageing [20]
PGK1	deacetylation	glycolysis [21]
GABPβ1	deacetylation	mitochondrial homeostasis [17,22,23]
U3-55k	deacetylation	pre-rRNA processing [24]
H3K122	desuccinylation	chromatin compaction [15]
FOXO3	deacetylation	monocyte apoptosis [25]
FKBP51	deacetylation	Akt activity [26]
CDK9	deacetylation	RNA polymerase II transcription [27]
DDB1	deacetylation	activity of the CUL4B/DDB1/DCAF1 E3 ubiquitin ligase complex [28]
DDX21	deacetylation	transcription elongation and genome stability [29]
SMAD4	deacetylation	breast cancer metastasis [30]
OSX	deacetylation	bone formation [31]
WDR77	deacetylation	transmethylase activity of the WDR77/PRMT5 complex [32]
Fibrillarin	deacetylation	rRNA synthesis [33]
H3K36/K37	deacetylation	heterochromatin silencing [34]
ATM	deacetylation	DNA repair [35]
Ran	deacetylation	nuclear export of NF-κB p65 [36]
H4K91	deglutarylation	chromatin structure [16]
GATA4	deacetylation	stress-induced cardiac hypertrophy
STRAP	deacetylation	p53 activity and stability [37]
CRY1	deacetylation	circadian phase coherence and glucose homeostasis [38]
Nfatc1	deacetylation	hair growth [39]
USP39	deacetylation	hepatocellular carcinoma development [40]