Figure 3.

Deletion of STAT1 does not ameliorate inflammation of Casp8^ΔIEC mice during DSS colitis. (A) Relative body weight of control, Casp8^ΔIEC, Casp8^ΔIECxStat1^−/−, Casp8^ΔIECxMlkl^−/− mice after administration of 2% DSS in drinking water. Mice were sacrificed at day 5. (B) Representative endoscopic pictures at day 5. Representative images of colonic cross sections stained with H&E (scale bar: 200 μm) or immunohistochemically stained (scale bar: 75 μm) with antibody against E-Cahderin (green). Nuclei were counterstained with Hoechst 33,342 (blue). (C) Endoscopic score. Error bars indicate +/-SD. Statistical analyses: One-way ANOVA with Tukey's multiple comparisons test; NS p ≥ 0.05; * p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. Pooled data of two individual experiments.