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Opa1-mediated mitophagy attenuates mitochondrial ROS production and reduces mitochondrial dysfunction. Control (nontransduced) and Ad-Opa1-transduced H9C2 cardiomyocytes were treated with 0.3 mM H2O2 for 12 h. (a, b) Fluorescent detection of ROS production. Bar: 15 μm. (c, d) Assessment of mitochondrial membrane potential via JC-1 staining. Bar: 40 μm. (e) Results of the mPTP opening assay. ∗p < 0.05 vs. control group, #p < 0.05 vs. H2O2+Ad-Ctrl group.
