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Opa1-mediated mitophagy sustains cardiomyocyte viability under oxidative stress. Control (nontransduced) and Ad-Opa1-transduced H9C2 cardiomyocytes were exposed to 0.3 mM H2O2 for 12 h. (a) Analysis of cardiomyocyte viability using the CCK-8 assay. (b, c) Assessment of apoptosis by TUNEL assay. Bar: 90 μm. (d–i) Western blotting analysis of Bax, caspase-9, caspase-12, Bcl-2, and c-IAP expression. ∗p < 0.05 vs. control group, #p < 0.05 vs. H2O2+Ad-Ctrl group.
