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. 2021 Jun 7;2021:3726885. doi: 10.1155/2021/3726885

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Copyright © 2021 Yue Wang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Opa1-mediated mitophagy activates the MAPK/ERK signaling pathway. Control (nontransduced) and Ad-Opa1-transduced H9C2 cardiomyocytes were treated with 0.3 mM H₂O₂ for 12 h. (a, b) Western blotting analysis of ERK and p-ERK expression. (c, d) Analysis of ERK and p-ERK expression through immunofluorescence. Bar: 75 μm. (e, f) Fluorescent detection of ROS production in cells pretreated with the MAPK/ERK inhibitor PD98059. Bar: 25 μm. ^∗p < 0.05 vs. control group, ^#p < 0.05 vs. H₂O₂+Ad-Ctrl group, ^@p < 0.05 vs. H₂O₂+Ad-Opa1 group.