Table II.
Summary of mice.
| Genotype | Age at surgery (days) | Age at death (days) | Cause of death/reason for sacrifice | Observations |
|---|---|---|---|---|
| Control | 42 | 43 | FD | Complications from surgery |
| Control | 35 | 103 | ED | No phenotype |
| Control | 35 | 103 | ED | No phenotype |
| Control | 35 | 103 | ED | No phenotype |
| Control | 42 | 403 | ES | No phenotype |
| Control | 45 | 406 | ES | No phenotype |
| Control | 45 | 406 | ES | No phenotype |
| Control | 45 | 406 | ES | No phenotype |
| Control | 48 | 418 | ES | No phenotype |
| LtfCre0/+; Arid1afl/+; (Gt)R26Pik3ca*H1047R | 39 | 71 | VB | |
| LtfCre0/+; Arid1afl/+; (Gt)R26Pik3ca*H1047R | 35 | 103 | VB | Lesion on ipsilateral ovary |
| LtfCre0/+; Arid1afl/+; (Gt)R26Pik3ca*H1047R | 42 | 112 | AB, VB | Lesions throughout peritoneum, organ anastomosis, ascites |
| LtfCre0/+; Arid1afl/+; (Gt)R26Pik3ca*H1047R | 45 | 112 | FD | |
| LtfCre0/+; Arid1afl/+; (Gt)R26Pik3ca*H1047R | 35 | 116 | VB | Intestinal anastomosis, ascites |
| LtfCre0/+; Arid1afl/+; (Gt)R26Pik3ca*H1047R | 45 | 120 | VB, DA | Ovarian lesions, intestinal anastomosis, ascites |
| LtfCre0/+; Arid1afl/+; (Gt)R26Pik3ca*H1047R | 48 | 126 | Distressed, VB | Lesions on both ovaries and omentum, intestinal anastomosis |
| LtfCre0/+; Arid1afl/+; (Gt)R26Pik3ca*H1047R | 48 | 162 | VB, DA | Ascites |
| LtfCre0/+; Arid1afl/fl; (Gt)R26Pik3ca*H1047R | 42 | 82 | Lethargic, pale | Lesion on cervix, blood in intestines |
| LtfCre0/+; Arid1afl/fl; (Gt)R26Pik3ca*H1047R | 33 | 92 | VB | |
| LtfCre0/+; Arid1afl/fl; (Gt)R26Pik3ca*H1047R | 45 | 94 | DA | Lesions on ovary and mesentery |
| LtfCre0/+; Arid1afl/fl; (Gt)R26Pik3ca*H1047R | 48 | 98 | ED | Lesion on ovary |
| LtfCre0/+; Arid1afl/fl; (Gt)R26Pik3ca*H1047R | 48 | 98 | ED | Intestinal anastomosis, ascites |
| LtfCre0/+; Arid1afl/fl; (Gt)R26Pik3ca*H1047R | 33 | 116 | VB | Intestinal anastomosis, ascites |
| LtfCre0/+; Arid1afl/fl; (Gt)R26Pik3ca*H1047R | 48 | 135 | Distressed, VB | Anemic intestines |
| LtfCre0/+; Arid1afl/fl; (Gt)R26Pik3ca*H1047R | 42 | 148 | AB, VB | Ipsilateral ovary fused with kidney, ascites |
| LtfCre0/+; Arid1afl/fl; (Gt)R26Pik3ca*H1047R | 42 | 176 | VB | Lesion on ovary |
| LtfCre0/+;(Gt)R26mTmG | 54 | 149 | ED | No phenotype |
| LtfCre0/+;(Gt)R26mTmG | 33 | 94 | ED | No phenotype |
| LtfCre0/+;(Gt)R26mTmG | 64 | 125 | ED | No phenotype |
| LtfCre0/+; Arid1afl/fl; (Gt)R26Pik3ca*H1047R/mTmG | 28 | 123 | VB | Lesion on omentum, abdominal wall |
| LtfCre0/+; Arid1afl/fl; (Gt)R26Pik3ca*H1047R/mTmG | 38 | 99 | VB | Lesion on ovary |
| LtfCre0/+; Arid1afl/fl; (Gt)R26Pik3ca*H1047R/mTmG | 33 | 92 | VB | Lesion on abdominal wall |
| LtfCre0/+; Arid1afl/fl; (Gt)R26Pik3ca*H1047R/mTmG | 33 | 116 | VB | Lesion on omentum |
Summary of mice. VB, vaginal bleeding; AB, abdominal bulge; FD, found dead; DA, distended abdomen; ES, end of study; ED, explorative dissection.