Figure 1.

Miami plot showing results of sex-stratified multiancestry genome-wide fixed-effects meta-analyses in chromosomes 1–22, highlighting a new significant locus in Chr10p12.31 in males and confirming known loci on chromosome 19 and 6 in both sexes. Association P values are shown for the female-specific (top) and male-specific (bottom) meta-analyses. The red line indicates a genome-wide association study (GWAS) significant threshold (P = 2.05 × 10⁻⁰⁷), and the yellow line, to a GWAS suggestive threshold (P = 5 × 10⁻⁰⁵). Abbreviations: ARL5B, adenosine diphosphate–ribosylation factor–like 5B; Chr, chromosome; IFNL4, interferon lambda 4.