Table 2.
Top Associated Variants With Hepatitis C Virus Spontaneous Clearance in Multiancestry Meta-analyses in Male and Female Participants
| Males Participants (n = 2903) | Female Participants (n = 1520) | |||||||
|---|---|---|---|---|---|---|---|---|
| Nearby Gene and Associated SNPs | Chromosome: Position (GRCh37/ hg19) | Effect allele | Effect Allele Frequency | OR | P Value | Effect Allele Frequency | OR | P Value |
| HLA-DQB1, HLA-DQA2 | ||||||||
| rs2647006 | 6:32 660 582 | C | 0.64 | 1.69 | 2.9 × 10–11 | 0.63 | 1.97 | 3.93 × 10−12 |
| rs2858319 | 6:32 661 294 | C | 0.64 | 1.68 | 4.0 × 10−11 | 0.63 | 1.98 | 3.0 × 10−12 |
| rs9275521 | 6:32 674 952 | C | 0.64 | 1.69 | 2.6 × 10−11 | 0.64 | 1.96 | 6.9 × 10−12 |
| ARL5B | ||||||||
| rs76398191 | 10:19 108 059 | C | 0.31 | 0.69 | 1.9 × 10−07 | 0.32 | 1.01 | 0.94 |
| rs12573426 | 10:19 081 778 | A | 0.30 | 0.69 | 3.7 × 10−07 | 0.31 | 1.04 | 0.65 |
| IFNL3–IFNL4 | ||||||||
| rs12979860 | 19:39 738 787 | C | 0.54 | 2.48 | 5.8 × 10−24 | 0.52 | 2.46 | 2.5 × 10−20 |
| rs778086851 | 19:39 739 153 | CT | 0.52 | 2.52 | 7.4 × 10−25 | 0.51 | 2.50 | 4.6 × 10−21 |
| rs74597329 | 19:39 739 155 | T | 0.52 | 2.53 | 3.9 × 10−25 | 0.51 | 2.50 | 5.0 × 10−21 |
Abbreviations: ARL5B, adenosine diphosphate–ribosylation factor–like 5B; GRCh37/hg19, Genome Reference Consortium Human genome build 37/Human Genome version 19; IFNL4, interferon lambda 4; IFNL3, interferon lambda 3; OR, odds ratio for hepatitis C virus spontaneous clearance; SNP, single-nucleotide polymorphism.