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A. Thrombin forms fibrin monomers by cutting fibrinopeptides from the fibrinogen E-domain.
B. Fibrin monomers aggregate.
C. Fibrin monomers become cross‐linked by factor XIIIa to produce a fibrin clot.
D. The breakdown of cross‐linked polymers by plasmin results in the release of fibrin degradation products, including D‐dimer.
