Table 1.
Details of neurological score
Spontaneous activity |
Normal (3) |
Slightly affected (2) |
Severely affected (1) |
No movement (0) |
Symmetry in movement of 4 limbs assessed when rat held suspended by tail |
Symmetric (3) |
Asymmetric (2) |
Hemiplegic (1) |
Forepaw outstretching assessed by bringing rat to edge of table and making it walk on forelimbs while being held by tail and observing forelimb use |
Symmetric forepaws (3) |
Mild asymmetry (2) |
Marked asymmetry (1) |
One forelimb did not move (0) |
Climbing determined by placing rat on the wall of a wire cage and observing climbing and strength of attachment to wall |
Climbed easily, gripped tightly (3) |
One side impaired (2) |
Failed to climb or tended to circle instead of climbing (1) |
Body proprioception |
Equal on both sides (3) |
Reacted slowly to stimulus on 1 side (2) |
No response on one side (1) |
Response to vibrissae touch determined by brushing vibrissae on each side |
Symmetric (3) |
Asymmetric (2) |
No response on 1 side (1) |