Figure 6.

OCLN overexpression partly reversed the effect of miR-122-5p on BMECs. A: OCLN mRNA expression in BMECs treated with miR-122-5p exosomes or OCLN; B: Cell activity; C, D: Colony formation ability; E, F: Cell apoptosis; G-I: SOD, CAT, ROS and MDA levels; J, K: ZO-1, Claudin-5 and VEGF protein expressions. Compared with the control or vector group, ^ΔP<0.05; compared with the miR-mimic-exo + vector group, ^▲P<0.05. OD: optical density; ROS: reactive oxygen species; MDA: malondialdehyde; SOD: superoxide dismutase; CAT: catalase; NC: negative control; VEGF: vascular endothelial growth factor.