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Total number of gene variants detected in CTCs and primary tumors. The data were evaluated for the CTC and primary tumor samples and averaged to minimize errors. As shown in the Figure, several of the mutations are found more frequently in CTCs (e.g., more mutations in BRAF, KRAS, and PIK3CA genes), indicating that only cell populations with these mutations are circulating in the blood and may be prognostic factors for more aggressive disease.
