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. 2021 May 17;128(6):771–791. doi: 10.1007/s00702-021-02353-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Representative localization of SMI-32 in neuromuscular junction (NMJ) in WT and SMA mice. Electron micrograph from WT mouse a showing a normal, well conformed NMJ. SMI-32 immuno-gold particles (arrows) are barely detectable within the a well-organized cytosol. b In SMA mouse, the normal NJM architecture is completely lost and sub-cellular compartments are no longer distinguishable, while a strong SMI-32 immuno-gold staining is evident (arrows). The graph c reports the number of SMI-32 immuno-gold particles in SMA and WT mice. Values are the mean number ± S.E.M. of 10 NMJ per mouse (100 NMJ per group). Scale bar: a, b = 0.3 µm. *P ≤ 0.05 compared with WT. M mitochondria