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SIRT2 removes lactoylLys modifications in vitro. (A) Sirtuin localization in cells. (B) Sirtuins 1-7 incubated with lactoylLys modified peptides. N = 3; *p < 0.05; ***p < 0.001, ± S.D. Statistical significance determined via One-Way ANOVA. (C) Kinetic parameters for SIRT2 on acetylated and lactoylated peptides. N = 3; Km ± S.E.; Kcat ± S.E.
