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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: DNA Repair (Amst). 2021 Apr 20;103:103126. doi: 10.1016/j.dnarep.2021.103126

Figure 4.

Figure 4.

Role of TC-NER in causing mutational strand asymmetry. Upper panel: Damage (e.g., UV-induced TC dimer) located on the transcribed strand (TS) stalls Pol II elongation and is repaired by TC-NER. The fast repair leads to low C>T mutation frequency on the TS. Lower panel: A TC dimer located on the non-transcribed strand (NTS) cannot be repaired by TC-NER and is left for repair by GG-NER. The slow repair by GG-NER causes high C>T mutation frequency on the NTS when the damage is replicated by a DNA polymerase.