Table 3:

Group-level statistics from linear mixed effects models predicting gray matter volume of ROIs from clinical group and editing method.

ROI	Group Main Effect (NTC vs. PTSD)			Group Main Effect (TEC vs. PTSD)			Method Main Effect			Group*Met hod Interaction (NTC vs. PTSD)		Group*Met hod Interaction (TEC vs. PTSD)
	t(250)	p-value	Cohe n’s d	t(250)	p-value	Cohe n’s d	t(250)	p-value	Cohe n’s d	t(250)	p-value	t(250)	p-value
Left Hemisphere
Amygdala	2.68	.008	0.483	2.10	.037	0.386	0.43	.670	0.076	0.82	.416	−0.29	.771
Hippocampus	1.55	.122	0.280	1.60	.111	0.290	0.17	.868	0.030	0.60	.550	−0.70	.488
rACC	−0.01	.992	0.009	−0.02	.981	0.101	11.61	<.001	0.262	0.29	.774	−0.99	.324
Temporal Lobe	−0.97	.333	0.175	−0.01	.997	0.002	<0.01	.998	<.001	0.33	.741	0.70	.483
Right Hemisphere
Amygdala	1.13	.261	0.204	1.17	.242	0.212	0.06	.953	0.010	0.79	.429	.001	.995
Hippocampus	1.93	.055	0.347	1.50	.134	0.273	0.18	.86	0.031	0.92	.359	−0.19	.853
rACC	−0.62	.533	0.122	−2.26	.025	0.408	1.83	.068	0.326	−1.39	.165	−0.98	.426
Temporal Lobe	−0.77	.445	0.129	−0.32	.750	0.059	0.87	.445	0.160	−0.01	.991	−0.53	.594
Whole Brain
Total Cortical Volume	−1.82	.070	0.311	−1.17	.243	0.219	−1.62	.106	0.289	−0.45	.657	−1.27	.206
Total Gray Matter Volume	−1.45	.148	0.248	−0.84	.402	0.157	−1.55	.123	0.276	−0.36	.716	−1.21	.227

rACC = rostral anterior cingulate cortex. Bolded values in table indicate significant differences after Bonferroni correction for multiple comparisons (for family-wise Bonferroni correction, the amygdala, hippocampus, rACC, and temporal lobe were each considered a family with four tests (right and left hemisphere for each group and CTQ (Table S1) as predictors of interest); therefore, the p-value threshold for significance was set at 0.0125).