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. Author manuscript; available in PMC: 2022 Jun 14.
Published in final edited form as: Cancer Cell. 2021 Apr 22;39(6):759–778. doi: 10.1016/j.ccell.2021.03.010

Figure 3. The landscape of genetic alterations within the core cell-cycle machinery genes.

Figure 3.

Data according to The Cancer Genome Atlas PanCancer (n=10,967 samples). Shown is the frequency of alterations within groups of the indicated cell-cycle genes. Ten most affected cancer types are shown for each group, together with percentages of cases displaying genetic alterations. Tumor type designation: ACC - Adrenocortical Carcinoma; BLCA - Bladder Urothelial Carcinoma; BRCA - Breast Invasive Carcinoma; CESC - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma; CHOL – Cholangiocarcinoma; COADREAD - Colorectal Adenocarcinoma; DLBC - Diffuse Large B-cell Lymphoma; ESCA - Esophageal Carcinoma, GBM - Glioblastoma Multiforme, HNSC - Head and Neck Squamous Cell Carcinoma, LIHC - Liver Hepatocellular Carcinoma, LUAD – Lung Adenocarcinoma, LUSC- Lung Squamous Cell Carcinoma, MESO – Mesothelioma, OV - Ovarian Serous Cystadenocarcinoma, PAAD - Pancreatic Adenocarcinoma, PRAD - Prostate Adenocarcinoma, SARC – Sarcoma, SKCM - Skin Cutaneous Melanoma, STAD - Stomach Adenocarcinoma, UCEC - Uterine Corpus Endometrial Carcinoma, UCS - Uterine Carcinosarcoma, UVM - Uveal Melanoma.