Table 1.
Licensed Japanese encephalitis (JE) vaccines.
| Vaccine type | Substrate | Viral strains | WHO-prequalified manufacturers | WHO recommended vaccine schedule | Other manufacturers (domestic and traveler markets) |
|---|---|---|---|---|---|
| Inactivated | Mouse brain | Nakayama | n/a | n/a | Vietnam: Vabiotech |
| Vero | Beijing-1 | n/a | n/a | Japan: Biken (Research Foundation for Microbial Diseases of Osaka University), Kaketsuken (The Chemo-Sero-Therapeutic Research Institute, Korea: Boryung Pharmaceutical Co., Ltd (fill-finish of Kaketsuken vaccine) | |
| Vero | Beijing P-3 | n/a | n/a | China: Liaoning Chengda Biotechnology Co | |
| Vero | SA 14-14-2 | India: Biological E | Two doses 28 days apart, from 1 year of age | Austria: Valneva Austria GmbH | |
| Vero | Kolar strain (JEV 821564XY) | n/a | n/a | India: Bharat Biotech | |
| Live attenuated | Hamster kidney cells | SA 14-14-2 | China: Chengdu Institute of Biological Products | Single dose at ≥8 months of age | Wuhan Institute of Biological Products |
| Live chimeric | Vero | JE SA 14-14-2/yellow fever 17D | Thailand: Government Pharmaceutical Organization-Merieux Biological Products Co. | Single dose at ≥9 months of agea | n/a |
Adapted from Halstead et al.1.
aManufacturer recommends pediatric booster 1–2 years after the primary dose.