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. 2021 Jun 15;7:147. doi: 10.1038/s41420-021-00525-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A A Kaplan–Meier survival analysis for RCC patients according to miR-155-5p expression in the TCGA databases. B The expression levels of miR-155-5p in RCC tissues were significantly higher than that in normal kidney tissues (ENCORI, http://starbase.sysu.edu.cn/). C, D In our 79 pairs of primary RCC cohort, the differences of significant overregulation of miR-155-5p between patients with high or low ISUP grade and AJCC stage were determined by qRT–PCR. E Immunohistochemistry analysis of CD163 and HIF-1a. Representative photographs are shown (×200 and ×400 magnifications). F, G A plot of the relative expression of miR-155-5p vs. HIF-1a and CD163 staining showed their positive correlations in our cohort. Correlation index r was calculated using Spearman rank test.