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. 2021 Jun 15;11:12514. doi: 10.1038/s41598-021-91682-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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PLNC8 αβ antagonizes S. aureus-induced cytotoxicity and modulates the inflammatory responses of human keratinocytes. (A) Representative images of HaCaT cells after infection with S. aureus for 1 h followed by addition of PLNC8 αβ for 6 h, scale bar is 50 µm. (B) PLNC8 αβ antagonized S. aureus-mediated cytotoxicity, which was determined by measuring LDH activity, and promoted cell viability. The secretion of (C) IL-6 and (D) CXCL8 was significantly reduced by the peptides, except the highest dose (25 µM), which increased IL-6 secretion. *p < 0.05; **p < 0.01; ***p < 0.001 (One-way ANOVA with Sidak’s post-hoc test).