Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 15;11:12514. doi: 10.1038/s41598-021-91682-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

PLNC8 αβ inhibits S. aureus growth and bacteria-induced cytotoxicity of human keratinocytes. HaCaT cells were infected with MSSA, in the presence or absence of PLNC8 αβ for 93 h. PLNC8 αβ inhibited S. aureus growth at (A) MOI:0.1 and (B) MOI:1 in a dose-dependent manner for at least 93 h, and markedly enhanced the effect of low dose gentamicin. S. aureus caused cell death after 11 h (MOI:0.1) and 7 h (MOI:1), as indicated by the dotted lines and markers below each graph. PLNC8 αβ efficiently counteracted this effect in a dose-dependent manner. The combination of PLNC8 αβ with gentamicin synergistically inhibited S. aureus growth and counteracted bacteria-induced cell death. The y-axis represents fluorescence intensity expressed as arbitrary units (AU/well).