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. 2021 Jun 15;12(6):615. doi: 10.1038/s41419-021-03882-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Representative capillary tubule structures were shown for HUVECs treated with culture medium collected from the indicated LN229 and U87MG cells. Scale bar represents 50 μm. B Blood vessels formed in representative images of the CAM assay after CM treatment. C Transwell assay was performed in HUVECs to detect the effect of CM treatment on cell migration. Scale bar represents 50 μm. D RT-qPCR detects the effects of Prrx1 on the expression of classical proangiogenic factors in U87MG and LN229 cells (mean ± SD, n = 3). E IF assay analysis of glioma specimens showed the vessel density in regions with different Prrx1 expression levels. The H indicated regions with high expression level of Prrx1 and the L indicated regions with low Prrx1 expression. Representative images of three cases were shown. Scale bar represents 10 μm. *P < 0.05, **P < 0.01, ***P < 0.001.