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. 2021 Jun 15;12(6):615. doi: 10.1038/s41419-021-03882-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Effects of TGF-β pathway agonist SRI-011381 and TGF-β1 siRNA on Prrx1 mediated NSTCs stemness acquisition through sphere formation assay. B Effects of SRI-011381 and TGF-β1 siRNA on Prrx1 mediated NSTCs angiogenesis through tubule formation assay. C Transwell assay indicated the effects of SRI-011381 and TGF-β1 siRNA on Prrx1 mediated migration of HUVEC treated with NSTCs CM. Scale bar represents 50 μm. D Effects of SRI-011381 and TGF-β1 siRNA on Prrx1 mediated GSCs stemness maintenance through sphere formation assay. E Effects of SRI-011381 and TGF-β1 siRNA on Prrx1 mediated GSCs angiogenesis through tubule formation assay. F Transwell assay indicated the effects of SRI-011381 and TGF-β1 siRNA on Prrx1-mediated migration of HUVEC treated with GSCs CM. Scale bar represents 50 μm. G, H Effects of SRI-011381 and TGF-β1 siRNA on Prrx1 induced TGF-β1 secretion in NSTCs (G) and GSCs (H) through ELISA assay. I, J Effects of SRI-011381 and TGF-β1 siRNA on expression changes of stemness markers (CD133 and SOX2) and TGF-β/smad pathway proteins (TGF-β1, P-smad2, and P-smad3) modulated by Prrx1 in NSTCs (I) and GSCs (J). *P < 0.05, **P < 0.01, ***P < 0.001.