Fig. 1. Wip1 deficiency in hematopoietic cells suppresses the growth of solid tumors.

a Age-stratified lymphocyte and granulocyte numbers in peripheral blood of Ppm1d^fl/fl and Ppm1d^Fes-Cre (Ppm1d^fl/fl;Fes-Cre) mice (n = 12 each genotype). b Tumor volume (left) and tumor growth area under the curve (AUC) (right) for growth of B16 F10 melanoma in Ppm1d^fl/fl (n = 5) and Ppm1d^Fes-Cre (n = 6) mice. c Tumor volume (left) and AUC (right) for growth of B16 F10 tumors in Ppm1d^fl/fl and Ppm1d^KO2/KO2 (n = 5 each genotype). d Tumor volume (left) and AUC (right) for growth of B16 F10 tumors in lethally irradiated WT mice with subsequent adoptive transfer of WT or Ppm1d^KO2/KO2 bone marrow (BM) cells (n = 4 each genotype). e Tumor volume (left) and AUC (right) for growth of LLC1 lung carcinoma tumors in Ppm1d^fl/fl and Ppm1d^ΔHSC mice (n = 6 each genotype). f Tumor volume (left) and AUC (right) for growth of LLC1 tumors in Ppm1d^fl/fl, Ppm1d^Fes-Cre, and Tg(UbC-Ppm1d) mice (n = 4 each genotype). Data are depicted as means ± SEM. Student’s t test (two-tailed) (b–e), ordinary one-way ANOVA (f), and ordinary one-way ANOVA with Sidak’s multiple comparison test (a): *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001 (one representative experiment out of 3 is shown for Panel b–f). Source data are provided as a Source Excel Data file.