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. 2021 Jun 15;11:12554. doi: 10.1038/s41598-021-91464-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Establishment of a novel anti-CLDN15 mAb suitable for IHCs. a Schematic representation of the domain structure of human CLDN15 protein. The region corresponding to the peptide used for the immunization is shown in orange. b Amino-acid sequence of the cytoplasmic tail of CLDN15 and alanine mutants used in this study. Alignment with other CLDNs is also shown. c IHC of HEK293T cells expressing CLDNs. Note that 2C11 specifically stains only CLDN15-expressing cells. d Epitope analysis of 2C11. Note that 2C11 signal is lost in mutants 9–19, indicating that the epitope is ²¹⁹FGKYGRNA²²⁶ of CLDN15. e Amino-acid sequences of CDRs of 2C11.