. 2021 Jun 15;12:3635. doi: 10.1038/s41467-021-23838-x

Table 1.

Response variability decreases with stimulus size.

Experiment	FF decrease (½ RF)–(1 RF)	FF decrease (1 RF)–(2 RF)	p Value	Mean-matched FF decrease (size < RF)–(size > RF)	p Value
1. Natural, awake (N = 86; Fig. 2f)	18.7%	5.7%	0.0082	25.7%	<10⁻⁵
2. Gratings, awake (N = 19; Supplementary Fig. S4)	31.7%	9.0%	0.05	47.7%	<10⁻³
3. Gratings, anesthetized (N = 229; Supplementary Fig. S4)	14.2%	7.0%	<10⁻³	22.6%	<10⁻⁵

Experiment

FF decrease
(½ RF)–(1 RF)

FF decrease
(1 RF)–(2 RF)

p Value

Mean-matched FF decrease
(size < RF)–(size > RF)

p Value

1. Natural, awake

(N = 86; Fig. 2f)

18.7%

5.7%

0.0082

25.7%

<10⁻⁵

2. Gratings, awake

(N = 19; Supplementary Fig. S4)

31.7%

9.0%

0.05

47.7%

<10⁻³

3. Gratings, anesthetized

(N = 229; Supplementary Fig. S4)

14.2%

7.0%

<10⁻³

22.6%

<10⁻⁵

Rows: separate experiments, with number of neurons selected in each experiment (inclusion criteria in Methods). Columns: Column 1, experiments. Columns 2–4, changes in FF with stimulus size. Columns 5 and 6, mean-matched (see Methods) change in FF with stimulus size. In all cases, a positive change denotes a reduction in FF for larger stimuli. Column 2: change in FF (Methods, Eq. 5) from the stimulus closest to ½ of the RF size (out of all tested sizes) to the RF-sized stimulus. Column 3: change in FF from the RF-sized stimulus to the large stimulus (closest to 2 × RF size). Column 4: the p value for the second column. Column 5: FF change from stimuli smaller to larger than RF size. Sizes are selected to match the mean spike count across neurons (spike count change <3%, p > 0.05, for all experiments). Column 6: p value for column 5. The p values were computed with a one-sided paired samples t test of the null hypothesis that the difference between the two conditions had mean ≤ 0.