Table 1.
Participant Demographics
| rsfMRI | DTI | rsfMRI + DTI | ||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ISMMS | Olin | BSNIP-1 | BSNIP-2 | ISMMS | Olin | BSNIP-1 | BSNIP-2 | ISMMS | Olin | BSNIP-1 | BSNIP-2 | |||||||||||||
| HC N=47 |
Psych N=96 |
HC N=167 |
Psych N=102 |
HC N=97 |
Psych N=237 |
HC N=51 |
Psych N=90 |
HC N=52 |
Psych N=127 |
HC N=180 |
Psych N=96 |
HC N=86 |
Psych N=213 |
HC N=35 |
Psych N=70 |
HC N=47 |
Psych N=94 |
HC N=147 |
Psych N=83 |
HC N=63 |
Psych N=173 |
HC N=31 |
Psych N=64 |
|
|
|
||||||||||||||||||||||||
| Demographics | ||||||||||||||||||||||||
| Age (years (sd.)) | 29.0 (7.6) |
27.2 (7.6) |
39.8 (14.2) |
42.0 (13.0) |
40.4 (12.2) |
35.0 (12.2) |
30.8 (12.9) |
37.6 (11.5) |
29.8 (8.3) |
27.2 (7.6) |
40.3 (14.0) |
41.6 (12.4) |
39.5 (12.4) |
34.4 (12.1) |
30.4 (12.5) |
38.8 (12.0) |
29.0 (7.6) |
27.1 (7.6) |
39.6 (14.0) |
41.7 (12.8) |
40.2 (12.3) |
34.9 (12.0) |
30.8 (12.9) |
39.0 (12.2) |
| Sex, male, n(%) | 27 (57%) |
69 (72%) |
86 (52%) |
54 (53%) |
36 (37%) |
136 (57%) |
22 (43%) |
37 (41%) |
31 (60%) |
93 (73%) |
93 (52%) |
56 (58%) |
38 (44%) |
125 (59%) |
14 (40%) |
28 (40%) |
27 (59%) |
68 (72%) |
76 (52%) |
47 (57%) |
26 (41%) |
99 (57%) |
11 (35%) |
26 (41%) |
| Educationa | 5.4 (1.0) |
3.9 (1.3) |
3.9 (1.4) |
3.4 (1.2) |
14.9 (2.4) |
13.3 (2.2) |
14.8 (2.2) |
13.0 (2.2) |
5.3 (1.0) |
3.9 (1.3) |
3.9 (1.5) |
3.5 (1.2) |
15.0 (2.4) | 13.2 (2.2) |
14.6 (2.3) |
13.1 (2.4) |
5.4 (1.0) |
3.9 (1.3) |
3.9 (1.4) |
3.5 (1.2) |
14.8 (2.3) |
13.3 (2.2) |
14.8 (2.2) |
12.9 (2.3) |
| IQ (sd.)b | 117.4 (16.2) |
96.3 (16.1) |
91.5 (13.2) |
87.4 (11.9) |
97.6 (15.4) |
97.2 (14.9) |
100.6 (11.0) |
95.2 (14.0) |
116.1 (16.7) |
96.3 (16.4) |
90.5 (13.2) |
88.3 (13.1) |
97.2 (15.6) |
98.4 (15.0) |
100.1 (12.3) |
97.3 (15.1) |
117.4 (16.2) |
96.5 (15.9) |
91.4 (13.3) |
87.6 (12.1) |
97.6 (14.6) |
98.2 (14.5) |
101.6 (11.8) |
96.0 (14.7) |
| Race n (%) | ||||||||||||||||||||||||
| Caucasian | 19 (40%) |
17 (17%) |
57 (58%) |
129 (54%) |
20 (40%) |
38 (42%) |
19 (37%) |
22 (17%) |
53 (61%) |
121 (57%) |
10 (29%) |
30 (43%) |
19 (41%) |
16 (17%) |
39 (62%) |
97 (56%) |
10 (33%) |
26 (41%) |
||||||
| African American | 12 (26%) |
40 (42%) |
167 (100%) |
102 (100%) |
28 (29%) |
75 (32%) |
15 (29%) |
18 (20%) |
17 (33%) |
50 (39%) |
180 (100%) |
96 (100%) |
23 (27%) |
63 (30%) |
15 (43%) |
16 (23%) |
12 (26%) |
40 (42%) |
147 (100%) |
83 (100%) |
16 (25%) |
52 (30% |
12 (39%) |
16 (25%) |
| Other | 12 (26%) | 36 (38%) | 12 (12%) | 32 (14%) | 12 (24%) | 34 (37%) | 12 (23%) | 49 (39%) | 10 (11%) | 28 (13%) | 9 (26%) | 24 (34%) | 12 (26%) | 35 (37%) | 8 (13%) | 23 (13%) | 8 (25%) | 22 (34%) | ||||||
| Diagnosis Breakdown | ||||||||||||||||||||||||
| BPP n(%) | 19 (20%) |
12 (12%) |
50 (21%) |
11 (12%) |
31 (24%) |
12 (13%) |
49 (23%) |
11 (16%) |
19 (20%) |
12 (15%) |
35 (20%) |
9 (14%) |
||||||||||||
| SAD n(%) | 27 (28%) |
26 (26%) |
64 (27%) |
43 (48%) |
32 (25%) |
27 (28%) |
61 (29%) |
30 (43%) |
25 (27%) |
21 (25%) |
48 (28%) |
28 (44%) |
||||||||||||
| SZ n(%) | 47 (49%) |
46 (45%) |
123 (52%) |
36 (40%) |
59 (46%) |
45 (47%) |
103 (48%) |
29 (41%) |
47 (51%) |
40 (48%) |
90 (52%) |
27 (42%) |
||||||||||||
| MDD n(%) | 3 (3%) |
8 (8%) |
5 (4%) |
5 (5%) |
3 (3%) |
5 (6%) |
||||||||||||||||||
| Other n(%) | 10 (9%) |
7 (7%) |
5 (6%) |
|||||||||||||||||||||
| Symptoms | ||||||||||||||||||||||||
| YMRS (sd.) | _ | 8.3 (7.6) |
4.9 (5.8) |
10.7 (6.5) |
_ | 7.8 (6.8) |
5.2 (5.9) |
10.3 (6.8) |
_ | 7.7 (6.8) | 4.8 (5.6) |
10.3 (6.9) |
||||||||||||
| BPRS (sd.) | 50.9 (19.3) |
45.6 (11.8) |
_ | _ | 49.6 (18.9) |
44.8 (11.3) |
_ | _ | 51.0 (18.6) | 45.1 (11.5) | _ | _ | ||||||||||||
| PANSS (sd.) | ||||||||||||||||||||||||
| Positive | _ | _ | 14.6 (5.5) |
_ | 14.8 (5.1) |
_ | _ | 14.5 (5.4) |
14.6 (5.4) |
_ | _ | 14.5 (5.3) |
14.7 (5.3) |
|||||||||||
| Negative | _ | _ | 14.3 (5.3) |
_ | 13.9 (4.9) |
_ | _ | 14.1 (5.3) |
13.8 (4.7) |
_ | _ | 14.1 (5.4) |
14.0 (4.7) |
|||||||||||
| General | _ | _ | 28.2 (7.9) |
_ | 29.2 (5.9) |
_ | _ | 28.5 (7.8) |
29.3 (5.5) |
_ | _ | 28.0 (7.6) |
29.5 (5.6) |
|||||||||||
| Total | _ | _ | 57.0 (15.3) |
_ | 58 (13.2) |
_ | _ | 57.1 (15.2) |
57.7( 13.2) |
_ | _ | 56.6 (14.8) |
58.2 (13.2) |
|||||||||||
| Medications | ||||||||||||||||||||||||
| Lithium use, n(%) | 0 (0%) |
13 (14%) |
0 (0%) |
2 (2%) |
0 (0%) |
26 (11%) |
0 (0%) |
14 (16%) |
0 (0%) |
22 (18%) |
0 (0%) |
2 (2%) |
0 (0%) |
28 (13%) |
0 (0%) |
12 (17%) |
0 (0%) |
13 (14%) |
0 (0%) |
2 (2%) |
0 (0%) |
20 (12%) |
0 (0%) |
12 (19%) |
| Antipsychotic use, n(%) | 0 (0%) |
86 (90%) |
2 (1%) |
62 (61%) |
0 (0%) |
211 (89%) |
0 (0%) |
68 (76%) |
0 (0%) |
112 (88%) |
2 (1%) |
59 (62%) |
0 (0%) |
187 (88%) |
0 (0%) |
54 (78%) |
0 (0%) |
85 (90%) |
2 (1%) |
5 2(63%) |
0 (0%) |
156 (90%) |
0 (0%) |
49 (78%) |
Dashes indicate unavailable data; blank cells indicate data not applicable. rsfMRI=resting state functional MRI, DTI=Diffusion Tensor Imaging, BPP=Bipolar Disorder with Psychosis, SAD=Schizoaffective Disorder, SZ=Schizophrenia, MDD=Major Depressive Disorder with Psychosis, BPRS=Brief Psychiatric Rating Scale, YMRS=Young Mania Rating Scale, PNASS=Positive and Negative Symptom Scale
a
An 8-point scale from the SCID screener was used for Mount Sinai and Olin samples; Total years was used for BSNIP-1 and BSNIP-2 samples.
b
Estimated with the WASI for Mt. Sinai and Olin samples; Estimated with the WRAT for BSNIP1 and BSNIP2 samples