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. 2021 Jun 2;8:677727. doi: 10.3389/fcvm.2021.677727

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Copyright © 2021 Tan, Li, Zheng, Li, Zhang, Pyle, Chen, Wu, Sun, Zou, Backx and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tissue damage of atria, ventricles, and interventricular septum induced by DAC. There was widespread fibrosis (yellow arrows) in the myocardium of the left and right atria. Cardiomyocyte hypertrophy (green arrows) and eosinophil infiltration (red arrows) were observed in the right atrium. Cardiomyocyte hypertrophy (green arrows) and nuclear pyknosis (black arrows) were observed in the internal ventricular septum. Fibrosis (yellow arrows) was present in the left ventricular myocardium, accompanied by dissolved cardiomyocyte nuclei (blue arrows) and scar (blue circle) appearance. The right ventricle showed cardiomyocyte hypertrophy (green arrows) and interstitial fibrosis (yellow arrows).