Fig. 1. Genome-wide association study results for platelet aggregation and summary effects at 16 loci with P < 5 × 10−8.
A Genome-wide association study results for platelet aggregation in response to epinephrine, ADP and collagen in 3855 TOPMed participants. P values presented are a summary across all individual phenotypes for the single agonist (i.e., the minimum P value for the variants from 8, 7 and 4 individual phenotypes for epinephrine, ADP, and collagen, respectively described in Supplementary Table 1). P values are from a two-sided score test with no adjustment for multiple testing in panels A and B. Loci passing genome-wide significance (P < 5 × 10−8) are marked by red dots. Locus names represent the nearest (for novel) or previously annotated (for known) gene. The red line indicates a P value threshold of 5 × 10−8, corresponding to genome-wide significance. B Circle plot of the sentinel variant at the 16 loci for each of the 19 phenotypes showing strength of GWAS signal (second from center ring) and magnitude/direction of effect (center ring).