Figure 2.

Illustration of the gene-clustering algorithm

The list of genes harboring qualifying variants in five affected individuals is shown on the left, the center shows the background network in which edge thickness represents the edge weight and the bold edge is chosen as the clustering cutoff, and the gene cluster and corresponding case cluster generated are shown on the right (yellow indicates a new gene and a new case identified in each step of clustering; red indicates the genes and cases already in the cluster; white indicates the genes available for clustering; and gray indicates the genes closed for clustering).