Figure 2.

N-glycan abnormalities in serum from affected individuals

MALDI-TOF MS spectra of serum protein-derived N-glycans from unrelated individuals (P1, P4, and P6) are abnormal. Specifically, both high mannose (peaks at m/z 1,579.8 and 1,783.9) and hybrid type N-glycans (peaks at m/z 1,981.9, 2,186.1, and 2,390.2) increases were seen in positive-ion mode as sodiated forms. Green circles, mannose; yellow circles, galactose; blue squares, N-acetyl glucosamine; red triangles, fucose; purple diamonds, sialic acid.