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. 2021 Jun 2;11:659313. doi: 10.3389/fonc.2021.659313

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Copyright © 2021 Xu, Ma, Sun, Li and Gao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ROC analysis shows that SUV_max(AUC 0.668, 95% confidence interval (CI) 0.564-0.761, p=0.006) and SUV_peak (AUC 0.716, 95% CI 0.615-0.804, p<0.001) had a positive effect on disease progression. The optimal cut-off threshold values for SUV_max and SUV_peak were 9.12 g/cm³ (sensitivity 91.67, specificity 39.44), 7.63 g/cm³ (sensitivity 91.67, specificity 47.89), respectively. Kaplan-Meier survival graph shows significantly different PFS between the groups categorized by SUVmax and SUVpeak above and below cut-off value (p<0.05, log-rank test).