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The design and sequence of peptides 1–12. (A) The structure of MERS-CoV spike ectodomain showing the spike S1 and S2 subunits. (B) The fusion core showing trimers of HR1 and HR2 in a full fusion state. (C) Monomers of the fusion core showing HR1-HR2 binding. The site of fusion peptide design is represented by the bidirectional arrow. (D) The sequence of the synthesized peptides 1–12. The color scale indicates the degree of residue conservation.
