FIGURE 4.
Surface representation of electronic structure of PS1 Tyr256Ser and Ala260Val mutations: (A) the potential–potential surface of wild type (left) and mutation Tyr256Ser (right). Modification of the surface corresponding to position 256 can be observed; (B) density surface of wild type (left) and mutation Ala260Val (right), showing the increment in charges volume, blocking potential access to Asp257. The space around Tyr256 is used as a point of reference.