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. 2021 Jun 2;12:643935. doi: 10.3389/fgene.2021.643935

TABLE 2.

Univariable and multivariable Cox regression analyses of clinical characteristics.

Variables Univariate
Multivariate
P-value HR HR.95L HR.95H P-value HR HR.95L HR.95H
Age (> 50/ < 50) < 0.001 2.229 1.398 3.554 0.01 1.856 1.158 2.974
Gender (female/male) 0.79 1.043 0.764 1.425
Clinical stage (III–IV/I–II) < 0.001 3.734 2.716 5.134 0.002 2.871 1.465 5.624
M (M1–MX/M0) < 3.701 2.712 5.05 0.001 1.804 1.263 2.575
N (N1–NX/N0) 0.507 0.903 0.669 1.22
T (T3–T4/T1–T2) <0.001 3.042 2.242 4.127 0.419 0.78 0.426 1.427
Grade (G3–G4/G1–G2) <0.001 2.643 1.875 3.726 0.011 1.611 1.116 2.326
Risk score <0.001 2.553 1.977 3.296 < 0.001 2.07 1.537 2.789